The wide deployment of TD-LTE power wireless private network in smart grid demands an efficient and reliable security protection system. An end-to-end security protection system is presented for TD-LTE power wireless private network, in which specific methods are utilized to guarantee the security of access, transmission, core networks (three domains), user, control, management plane (three planes) and equipment, network, service layer (three layers), thus reducing the security risks brought by the open wireless channel, shared wireless network and mobile wireless terminal, and ensuring the safe end-to-end transmission and the reliable operation of the system.