With the rapid development of power grid business and the improvment of management requirement, the current power grid operation smart system zone Ⅲ Web with scattered maintenance/management cannot meet the development requirements of power grid and the requirements of secondary system integration construction of China Southern Power Grid. An integrated power gird operation smart system zone Ⅲ Web scheme based on Citrix is put forward. The feasibility and system architecture of the integrated power grid operation smart system zone Ⅲ Web based on Citrix are given, the key technologies of integrating the current zone Ⅲ Web relating to function reconstruction, server virtualization, function publishing, and system regulation and optimization are elaborated. Practical operation and tests show that the proposed scheme can satisfy the practical requirements, and improve the performance of the zone Ⅲ Web and the effectiveness of operation, maintenance and management.