This paper presents a comprehensive evaluation concept for multi-area interconnected grid. A comprehensive evaluation system of multi-area interconnected power grid with renewable energy considering uncertainties is constructed from the aspects of power supply access side, network itself, network connection and user side. This paper analyzes the uncertainty of each evaluation index from the aspects of change amount, change rate and sensitivity degree. It uses the fuzzy comprehensive evaluation method and the analytic hierarchy process to comprehensively judge and solve the model. The results of cases study show that the method can be used to judge the uncertainty in the actual operation of the interconnected power grid, which is instructive for the operation of power grid and the evaluation of online status.