Developing wind power is becoming the national energy strategy and will play an important role in economic development. Since there are differences in economic development, power grid structure, power consumption cost and electricity price level in different regions, finding a way to quantitatively evaluate comprehensive economy after wind power integration is helpful to guide wind power planning and construction. This paper proposes a comprehensive economy evaluation method from six aspects, including system operation cost, coal consumption and emission, conventional unit utilization hours, wind power subside cost, operating benefit of power grid company and coal fire plant electricity price. Then, taking a provincial power grid as an example, the comprehensive economy with large-scale wind power integration is evaluated, and the effectiveness of this method is verified.