In view of the current fact that under the background of the deepening of the coupling degree of various energy sources, the research on the evaluation method of asset utilization efficiency of integrated energy system needs to be carried out urgently, and the analysis of the operation status of integrated energy systems does not take into account the faulty operation status, etc., this paper proposes an integrated energy system asset utilization efficiency analysis method considering the load uncertainty and operation reliability. Firstly, a mathematical model that characterizing the uncertainty of the terminal load is constructed; Secondly, the system asset utilization efficiency and system operational reliability are used as indicators to evaluate the normal operation and fault operation status of the system, and the evaluation method is studied, and the indicators of different dimensions are combined by the membership function; Finally, through actual case simulation, the operation status of the integrated energy system throughout the year and typical days are specifically analyzed, and the uncertainty of load on the system asset utilization efficiency and operation reliability are analyzed. Thus the effectiveness and applicability of the theoretical methods mentioned in this article are verified.