In the traditional distribution network, substations often adjust and control the operation mode by changing the bus segment switch, so it is difficult to realize the real-time and continuous power regulation. In this paper, soft open point (SOP) is used to replace the segment switch of substation main transformer bus, and the related nodes of substation are flexibly interconnected to construct flexible interconnected nodes, so as to enhance the flexible power exchange control ability of power grid and realize power flow optimization. At the same time, in order to minimize the active power loss of the whole network, the scheduling SOP control variables and the switching of reactive power compensation equipment of relevant nodes are optimized. Because the problem involved belongs to mixed integer programming, a hybrid particle swarm optimization algorithm is proposed to solve the problem, and the effectiveness and rationality of the proposed strategy are verified in a high voltage distribution network.