In order to meet the requirements of users for thermal and electric energy and solve the problem of poor coordination performance of existing multi-energy coordination technologies, a multi energy coordination optimization technology considering the demand response of combined thermoelectricity is proposed. The mathematical model of combined heat and power supply is constructed by integrating energy production modes such as photovoltaic power generation, wind power generation, hydropower generation and gas-fired boiler heat generation. In this model, the thermal power demand is predicted according to the heating area and power consumption law of users, and the demand response mode is determined. The energy hub device is used to realize the conversion between energy and adjust the peak value of energy fluctuation. Under the constraints of lines, purchase and sale of electricity and other conditions, genetic algorithm is used to solve the mathematical model, expand the energy storage capacity and realize multi-energy coordinated optimization. It can be seen from the experimental results that after the application of this technology, it can meet the requirements of users from two aspects of thermal energy and electric energy, effectively reduce energy consumption, improve energy utilization, and have good coordination performance.