Aiming at the problem that the traditional voltage regulation strategy is difficult to deal with the two-way over-limit and violent fluctuation of the voltage after the high-permeability PV is connected to the medium voltage bus, and the importance of the load is not considered to affect the voltage regulation strategy. This paper proposes a distribution network voltage regulation strategy considering the importance of load and high permeability photovoltaic. Firstly, the importance index system of user load is constructed from three aspects: new energy efficiency, voltage quality and power load efficiency. Then, based on the combined variable weight method of improved AHP and improved CRITIC, the comprehensive weight of the index is determined, and then the importance coefficient of the load is determined. Secondly, according to the improvement level of voltage positive and negative deviation and voltage fluctuation after regulation, and combined with the important coefficient of load, the voltage regulation benefit function is constructed to measure the advantages and disadvantages of the regulation strategy. With the maximum regulation benefit as the optimization objective, the improved genetic algorithm is used to solve the voltage regulation strategy of distribution network in multi-time and multi-scenario. Finally, taking the improved IEEE 33-bus system as an example, the results show that the proposed strategy can effectively meet the voltage regulation requirements of high penetration photovoltaic access distribution network, and also take into account the guidance of user demand on voltage regulation strategy.