The operation strategy of an integrated energy system is crucial to achieve complementary advantages among various energy sources. Therefore, a day-ahead multi-objective optimal operation strategy for low carbon industrial integrated energy system based on knee point-driven is proposed. Firstly, the mathematical model of an electric-gas-heat industrial integrated energy system with an automatic assembly line production system is developed. Then, the multi-objective optimal operation model with the goal of minimizing the energy consumption cost and carbon emissions for the industrial integrated energy system is formulated. Finally, a knee point-driven approach is developed to solve the multi-objective optimization problem. Experimental results show that the knee point-driven multi-objective optimal operation strategy can make full use of time-of-use electricity price and the dispatchable loads to reduce energy cost and carbon emission.