A two-level interactive scheduling scheme is proposed to solve the demand response of the distribution network with microgrid groups. In this paper, a microgrid dispatch model and a multi-microgrid bidding model based on game theory are established. Firstly, Taking the lowest cost of each microgrid as objective, a demand response model based on time-of-use pricing mechanism and interruptible loads is employed, then the output of controlable units in microgrid is optimized. The results obtained will be used in the next game bidding process. The bidding strategy of each microgrid is determined by its offordable power output and operating cost, considering balanced index about the profits of each microgrid, then optimal bidding strategy is obtained. The validity of the proposed method and models is verified by simulation results based on IEEE9 system.